Introduction

The GenomEast Platform is hosted at the IGBMC (CNRS / University of Strasbourg / INSERM). With an experience of over 20 years, we offer a wide range of services to survey genomes, their expression and their regulation, from quality check of starting material up to data analysis. These services are intended for the entire scientific community, national and international, public and private.

Equipments

Bioinformatics

Personalized support for data analysis (RNA-seq, single cell RNA-seq, small RNA-seq, ChIP-seq, Cut&Run, Cut&Tag, ATAC-seq, MEDIP-seq, DNA-seq), from primary analysis to a large panel of in-depth secondary analysis through scientific collaborations. In particular, we have established RNA-seq, ChIP-seq and targeted DNA-seq pipelines using publicly available tools or in-house software.

Regular organization of training sessions on Next Generation Sequencing data analysis.

Main achievements

Over the past three years, the platform worked each year on about 300 projects (corresponding each year to about 3,000 sequenced libraries, 1,500 RNA-seq and 500 ChIP-seq libraries prepared), and the bioinformaticians from the platform analysed each year about 150 projects.

Members of the platform are co-authors of 50 publications over the last three years. Four of them are listed below:

Abu El Maaty et al. Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Science Advances (2022) 8(29):eabo2295.

Ibrahim et al. MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion. Science (2021) 372(6549):eabd5581.

Zhang et al. Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells. Nature communications (2021) 12(1):5446.

Vernet et al. Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. Science Advances (2020) 6(21):eaaz1139.

Last update September 2022