We propose the WES of 50 renal transplant pairs (100 exomes) in order to :
1-Refine the accuracy of the allogenomics method (described in this proposal) now in fully HLA-matched living related donors developing chronic rejection of their grafts.
2-Evaluate retrospectively the clinical relevance of WES in kidney-grafted population (recipient especially).
In particular, will WES be able to reassess the accuracy of the initial clinical diagnosis of the renal disease ? To date more than 30% of renal transplanted patients did not reach any pathological diagnosis of their nephropathy despite cost and efforts made by clinicians.