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Best of 2015

1. Institut Pasteur Thierry A. et al. Macrotene chromosomes provide insights to a new mechanism of high-order gene amplification in eukaryotes. Nat Commun. (2015) 6:6154.doi : 10.1038/ncomms7154.
2. ENS Carradec Q. et al. Primary and secondary siRNA synthesis triggered by RNAs from food bacteria in the ciliate Paramecium tetraurelia. Nucleic Acids Res. (2015) 43(3):1818-33. doi : 10.1093/nar/gku1331
3. ENS Boulay AC. et al. Immune quiescence of the brain is set by astroglial connexin 43. J Neurosci. (2015) doi:10.1523/JNEUROSCI.2575-14.2015
4. Génoscope de Vargas C et al. Eukaryotic plankton diversity in the sunlit ocean. Science (2015) doi:10.1126/science.1261605
5. MGX Al Adhami H et al. A systems-level approach to parental genomic imprinting : the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation. Genome Res. (2015) doi:10.1101/gr.175919.114
6. GenomEast Laurette P. et al. Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells. Elife. (2015) 4. doi:10.7554/eLife.06857.
7. GeT Roux al. Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation. G3 (Bethesda). (2015) 5(4):517-29. doi : 10.1534/g3.115.016865.
8. Génoscope Madoui al. Genome assembly using Nanopore-guided long and error-free DNA reads.
Bmc Genomics 2015, 16:327. doi : 10.1186/s12864-015-1519-z
9. Génoscope Pesant S. et al. Open science resources for the discovery and analysis of Tara Oceans data. Scientific data (2015) 2:150023. doi : 10.1038/sdata.2015.23
10. TGML Vanhille L. et al. (2015). High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Nat Commun. doi:10.1038/ncomms7905
11. TGML Zacarias-Cabeza,J. et al. Transcription-Dependent Generation of a Specialized Chromatin Structure at the TCRbeta Locus. J. Immunol. (2015) 194, 3432-3443. doi:10.4049/jimmunol.1400789
12. MGX Rodier G. et al. The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions. Cell Rep. (2015) 11:220-33
13. UCAGenomiX Saintamand A . et al. Elucidation of IgH 3’ region regulatory role during class switch recombination via germline deletion. Nat Commun. (2015) 6:7084. doi : 10.1038/ncomms8084.
14. GeT Chen H et al. Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat Commun. (2015) DOI : 10.1038/ncomms8095
15. Institut Curie Eleveld T.F. et al. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nature Genetics.doi : 10.1038/ng.3333
16. Génoscope Legendre M. et al. In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acanthamoeba. Proc.Na.Acad.Sci.U.S.A.(2015) 112(38) :E5327-E5335. doi : 10.1073/pnas.1510795112
17. Institut Pasteur Vembar SS et al. A. The PfAlba1 RNA-binding protein is an important regulator of translational timing in Plasmodium falciparum blood stages. Genome Biol. (2015) doi:10.1186/s13059-015-0771-5
18. Institut Curie Grünewald TGP. et al. Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. Nature Genetics (2015) DOI:10.1038/ng.3363
19. UCAGenomiX Chevalier B et al. miR-34/449 control apical actin network formation during multicilio genesis through small GTPase pathways. Nat Commun. (2015) DOI : 10.1038/ncomms9386.
20. Institut Curie Le Tourneau C.L. et al. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA) : a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. Lancet Oncol doi : 10.1016/S1470-2045(15)00188-6.
21. CNRGH Laustriat D. et al. In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin. Mol Ther Nucleic Acids (2015) 4p. e262 doi : 10.1038/mtna.2015.35.
22. CNRGH Mirzaa GM et al. Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria : a next-generation sequencing study. Lancet Neurol. (2015) doi:10.1016/S1474-4422(15)00278-1
23. GenomEast Portal MM. et al. TARDIS, a targeted RNA directional sequencing method for rare RNA discovery. Nat Protoc. (2015) (12):1915-38. doi : 10.1038/nprot.2015.120.
24. UCAGenomiX Crottès al. SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness. Cancer Res. 76(3):607-18. doi:10.1158/0008-5472.CAN-15-1465.
25. GenomEast Prasad MK et al. A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement. J Med Genet. Epub 2015 Oct 26. DOI : 10.1136/jmedgenet-2015-103302
26. Génoscope Kopylova E. et al. Deciphering metatranscriptomic data. Methods in molecular biology (Clifton, NJ), (2015) 1269:279-291. doi : 10.1007/978-1-4939-2291-8_17

update March 2017

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